- Abstract:
-
Adequate responses by our innate immune system toward invading pathogens were of vital importance for surviving infections, especially before the antibiotic era. Recently, a polymorphism in Mal (Ser180Leu, TIRAP rs8177374), an important adaptor protein downstream of the Toll-like receptor (TLR) 2 and 4 pathways, has been described to provide protection against a broad range of infectious pathogens. We assessed the functional effects of this polymorphism in human experimental endotoxemia, and ...
Expand abstract - Publisher copy:
- 10.1073/pnas.0811273106
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 106
- Issue:
- 25
- Pages:
- 10272-10277
- Publication date:
- 2009-06-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:1bcb771a-7301-43df-bfc0-54bf46ff5d6b
- Source identifiers:
-
95428
- Local pid:
- pubs:95428
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock.
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