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Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock.

Abstract:

Adequate responses by our innate immune system toward invading pathogens were of vital importance for surviving infections, especially before the antibiotic era. Recently, a polymorphism in Mal (Ser180Leu, TIRAP rs8177374), an important adaptor protein downstream of the Toll-like receptor (TLR) 2 and 4 pathways, has been described to provide protection against a broad range of infectious pathogens. We assessed the functional effects of this polymorphism in human experimental endotoxemia, and ...

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Publisher copy:
10.1073/pnas.0811273106

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
106
Issue:
25
Pages:
10272-10277
Publication date:
2009-06-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:1bcb771a-7301-43df-bfc0-54bf46ff5d6b
Source identifiers:
95428
Local pid:
pubs:95428

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