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Inappropriate major histocompatibility complex class II expression by thyroid follicular cells in thyroid autoimmune disease and by pancreatic beta cells in type I diabetes.

Abstract:

"Inappropriate" expression of class II major histocompatibility complex (MHC) molecules by target cells has been found in all organ-specific autoimmune diseases so far examined for the presence of this phenomenon. These glycoproteins may have a functional role as class II+ thyrocytes are able to present both small fragments of foreign antigens and autoantigens to helper T cells. Interferon gamma is a likely modulator of MHC class II expression in the thyroid but other signals like thyroid-sti...

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Publication status:
Published

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Authors


Pujol-Borrell, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Molecular biology and medicine
Volume:
3
Issue:
2
Pages:
159-165
Publication date:
1986-04-05
ISSN:
0735-1313
URN:
uuid:1bc99bca-ea0a-468b-85ed-178b86a463ff
Source identifiers:
481999
Local pid:
pubs:481999

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