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Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells.

Abstract:

PURPOSE: The resistance to selective EGFR inhibitors involves the activation of alternative signaling pathways, and Akt activation and VEGF induction have been described in EGFR inhibitor-resistant tumors. Combined inhibition of EGFR and other signaling proteins has become a successful therapeutic approach, stimulating the search for further determinants of resistance as basis for novel therapeutic strategies. EXPERIMENTAL DESIGN: We established human cancer cell lines with various degrees o...

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Publication status:
Published

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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
14
Issue:
16
Pages:
5069-5080
Publication date:
2008-08-01
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
Source identifiers:
312623

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