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Journal article

Application of ring-closing metathesis to Grb2 SH3 domain-binding peptides

Abstract:

Molecular processes depending on protein-protein interactions can use consensus recognition sequences that possess defined secondary structures. Left-handed polyproline II (PPII) helices are a class of secondary structure commonly involved with cellular signal transduction. However, unlike α-helices, for which a substantial body of work exists regarding applications of ring-closing metathesis (RCM), there are few reports on the stabilization of PPII helices by RCM methodologies. The current s...

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Publisher copy:
10.1002/bip.21692

Authors


Giubellino, A More by this author
Simister, PC More by this author
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Journal:
Biopolymers
Volume:
96
Issue:
6
Pages:
780-788
Publication date:
2011
DOI:
EISSN:
1097-0282
ISSN:
0006-3525
URN:
uuid:1bc47e99-b04a-4e09-9acd-091b716e9a12
Source identifiers:
343589
Local pid:
pubs:343589

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