Wnt2 is a direct downstream target of GATA6 during early cardiogenesis.

Journal article

The GATA4, 5 and 6 subfamily of transcription factors are potent transactivators of transcription expressed within the precardiac mesoderm. However, little is known of the immediate downstream targets of GATA-factor regulation during the earliest stages of cardiogenesis. Using the P19-CL6 embryonal carcinoma (EC) cell line as an in vitro model of cardiogenesis, we show that GATA6 is the most abundantly expressed of the GATA factors in presumptive cardiac cells. Consequently, we performed a mi...

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Authors: Alexandrovich, A; Arno, M; Patient, R; Shah, A; Pizzey, J

• Journal: Mechanisms of development
• Volume: 123
• Issue: 4
• Pages: 297-311
• Publication date: 2006-04-01
• DOI: 10.1016/j.mod.2006.02.002
• EISSN: 1872-6356
• ISSN: 0925-4773
• Language: English
• Keywords: Down-Regulation; Polymerase Chain Reaction; Oligonucleotide Array Sequence Analysis; Myocytes, Cardiac; Neoplastic Stem Cells; Gene Expression Regulation, Developmental; Base Sequence; Embryonic Development; Embryonal Carcinoma Stem Cells; Transfection; Animals; Heart; Cell Differentiation; Binding Sites; Up-Regulation; Wnt2 Protein; Promoter Regions, Genetic; Mice; GATA6 Transcription Factor; Cell Line, Tumor