The formation of the immunological synapse between a T cell and the antigen-presenting cell (APC) is critically dependent on actin dynamics, downstream of T cell receptor (TCR) and integrin (LFA-1) signalling. There is also accumulating evidence that mechanical forces, generated by actin polymerization and/or myosin contractility regulate T cell signalling. Because both receptor pathways are intertwined, their contributions towards the cytoskeletal organization remain elusive. Here, we identi...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Publisher's version
- Royal Society of Chemistry Publisher's website
- Integrative biology : quantitative biosciences from nano to macro Journal website
- Publication date:
- Source identifiers:
- Local pid:
- Copyright holder:
- Tabdanov et al.
- Copyright date:
- This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells.
If you are the owner of this record, you can report an update to it here: Report update to this record