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Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells.

Abstract:

The formation of the immunological synapse between a T cell and the antigen-presenting cell (APC) is critically dependent on actin dynamics, downstream of T cell receptor (TCR) and integrin (LFA-1) signalling. There is also accumulating evidence that mechanical forces, generated by actin polymerization and/or myosin contractility regulate T cell signalling. Because both receptor pathways are intertwined, their contributions towards the cytoskeletal organization remain elusive. Here, we identi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1039/c5ib00032g

Authors


Tabdanov, E More by this author
Gondarenko, S More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
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Funding agency for:
Dustin, ML
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Funding agency for:
Dustin, ML
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Integrative biology : quantitative biosciences from nano to macro Journal website
Volume:
7
Issue:
10
Pages:
1272-1284
Publication date:
2015-10-05
DOI:
EISSN:
1757-9708
ISSN:
1757-9694
URN:
uuid:1bb827a7-524a-4826-b3c9-f7a51d26cbd1
Source identifiers:
533220
Local pid:
pubs:533220
Language:
English

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