Journal article
Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells
- Abstract:
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The formation of the immunological synapse between a T cell and the antigen-presenting cell (APC) is critically dependent on actin dynamics, downstream of T cell receptor (TCR) and integrin (LFA-1) signalling. There is also accumulating evidence that mechanical forces, generated by actin polymerization and/or myosin contractility regulate T cell signalling. Because both receptor pathways are intertwined, their contributions towards the cytoskeletal organization remain elusive. Here, we identi...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Supplementary materials, 30.8MB)
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(Version of record, pdf, 5.7MB)
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- Publisher copy:
- 10.1039/c5ib00032g
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Authors
Funding
+ National Institutes of Health
More from this funder
Funding agency for:
Dustin, M
Grant:
PN2EY016586
PN2EY016586
Bibliographic Details
- Publisher:
- Royal Society of Chemistry Publisher's website
- Journal:
- Integrative Biology Journal website
- Volume:
- 7
- Issue:
- 10
- Pages:
- 1272-1284
- Publication date:
- 2015-07-09
- Acceptance date:
- 2015-07-01
- DOI:
- EISSN:
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1757-9708
- ISSN:
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1757-9694
- Source identifiers:
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533220
Item Description
- Language:
- English
- Pubs id:
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pubs:533220
- UUID:
-
uuid:1bb827a7-524a-4826-b3c9-f7a51d26cbd1
- Local pid:
- pubs:533220
- Deposit date:
- 2015-11-03
Terms of use
- Copyright holder:
- Tabdanov et al
- Copyright date:
- 2015
- Rights statement:
- This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
- Licence:
- CC Attribution (CC BY)
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