Journal article
Probing the nature of interactions in SH2 binding interfaces--evidence from electrospray ionization mass spectrometry.
- Abstract:
-
We have adopted nanoflow electrospray ionization mass spectrometry (ESI-MS) and isothermal titration calorimetry (ITC) to probe the mechanism of peptide recognition by the SH2 domain from the Src family tyrosine kinase protein, Fyn. This domain is involved in the mediation of intracellular signal transduction pathways by interaction with proteins containing phosphorylated tyrosine (Y*) residues. The binding of tyrosyl phosphopeptides can mimic these interactions. Specificity in these interact...
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- Publication status:
- Published
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- Publisher copy:
- 10.1110/ps.8.10.1962
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Authors
Bibliographic Details
- Journal:
- Protein science : a publication of the Protein Society
- Volume:
- 8
- Issue:
- 10
- Pages:
- 1962-1970
- Publication date:
- 1999-10-01
- DOI:
- EISSN:
-
1469-896X
- ISSN:
-
0961-8368
- Source identifiers:
-
59223
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:59223
- UUID:
-
uuid:1baba9d5-f373-4aa3-90f0-0ffb3f325e0f
- Local pid:
- pubs:59223
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1999
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