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Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway--a report of the Tumour Angiogenesis Research Group.

Abstract:

PURPOSE: Lactate dehydrogenase 5 (LDH-5) regulates, under hypoxic conditions, the anaerobic transformation of pyruvate to lactate for energy acquisition. Several studies have shown that serum LDH may be an ominous prognostic marker in malignant tumors. The clinical significance of tissue LDH-5, however, remains largely unexplored. PATIENTS AND METHODS: We investigated the immunohistochemical expression of LDH-5 in a series of 128 stage II/III colorectal adenocarcinomas treated with surgery a...

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Publication status:
Published

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Publisher copy:
10.1200/jco.2006.05.9501

Authors


Journal:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Volume:
24
Issue:
26
Pages:
4301-4308
Publication date:
2006-09-05
DOI:
EISSN:
1527-7755
ISSN:
0732-183X
URN:
uuid:1ba6b942-b208-41f6-b45a-a860c73e3f26
Source identifiers:
119309
Local pid:
pubs:119309

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