The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease.

Journal article

Alpha-Synuclein is thought to play an important role in the pathology of Parkinson's disease (PD). Truncated forms of this protein can be found in PD brain extracts, and these species aggregate faster and are more susceptible to oxidative stress than the full-length protein. We investigated the effect of truncated alpha-synuclein on dopaminergic cells using a transgenic mouse expressing alpha-synuclein (1-120) driven by the rat tyrosine hydroxylase promoter on a mouse alpha-synuclein null bac...

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Authors: Michell, A; Tofaris, G; Gossage, H; Tyers, P; Spillantini, MG

• Journal: Cell transplantation
• Volume: 16
• Issue: 5
• Pages: 461-474
• Publication date: 2007-01-01
• EISSN: 1555-3892
• ISSN: 0963-6897
• Language: English
• Keywords: Humans; Parkinson Disease; Animals; Embryo, Mammalian; alpha-Synuclein; Rats; Male; Mutant Proteins; Ventral Tegmental Area; Cells, Cultured; Peptide Fragments; Mice; Cell Size; Disease Models, Animal; Mice, Transgenic; Rotation; Dopamine; Mice, Inbred C57BL; Cell Count; Neurons; Substantia Nigra; Transgenes