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Effects of ionic strength on gating and permeation of TREK-2 K2P channels

Abstract:

In addition to the classical voltage-dependent behavior mediated by the voltage-sensing-domains (VSD) of ion channels, a growing number of voltage-dependent gating behaviors are being described in channels that lack canonical VSDs. A common thread in their mechanism of action is the contribution of the permeating ion to this voltage sensing process. The polymodal K2P K+ channel, TREK2 responds to membrane voltage through a gating process mediated by the interaction of K+ with its selectivity ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0258275

Authors


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Role:
Author
ORCID:
0000-0001-5175-1988
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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
ORCID:
0000-0001-6097-3646
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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Oxford college:
Green Templeton College
Role:
Author
ORCID:
0000-0001-8996-2000
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Name:
Biotechnology and Biological Sciences Research Council
Publisher:
Public Library of Science
Journal:
PLOS ONE More from this journal
Volume:
16
Issue:
10
Article number:
e0258275
Place of publication:
United States
Publication date:
2021-10-07
Acceptance date:
2021-09-22
DOI:
EISSN:
1932-6203
Pmid:
34618865
Language:
English
Keywords:
Pubs id:
1199949
Local pid:
pubs:1199949
Deposit date:
2021-12-26

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