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The effect of topology on the structure and free energy landscape of DNA kissing complexes.

Abstract:

We use a recently developed coarse-grained model for DNA to study kissing complexes formed by hybridization of complementary hairpin loops. The binding of the loops is topologically constrained because their linking number must remain constant. By studying systems with linking numbers -1, 0, or 1 we show that the average number of interstrand base pairs is larger when the topology is more favourable for the right-handed wrapping of strands around each other. The thermodynamic stability of the...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1063/1.4722203

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Theoretical Physics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Theoretical Physics
Role:
Author
Engineering and Physical Sciences Research Council More from this funder
Publisher:
American Institute of Physics Publisher's website
Journal:
The Journal of chemical physics Journal website
Volume:
136
Issue:
21
Pages:
215102
Publication date:
2012-06-05
DOI:
EISSN:
1089-7690
ISSN:
0021-9606
URN:
uuid:1ba5018f-0375-4a2d-a24a-7faaef3faa87
Source identifiers:
320486
Local pid:
pubs:320486
Language:
English
Keywords:

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