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Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis.

Abstract:

Following lymphocyte depletion, homeostatic mechanisms drive the reconstitution of lymphocytes. We prospectively studied this process in 16 patients for 1 year after a single pulse of treatment with Campath-1H, a humanised anti-CD52 monoclonal antibody. We observed two phases of lymphocyte reconstitution. In the first 6 months after treatment the precursor frequency and proliferation index of the patients' autologous mixed lymphocyte reaction increased; the depleted T cell pool was dominated ...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200535075

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Journal:
European journal of immunology
Volume:
35
Issue:
11
Pages:
3332-3342
Publication date:
2005-11-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Source identifiers:
12615

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