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Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

Abstract:

Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are unclear. In this study, we analyzed somatic alterations in mtDNA from 1675 tumors. We identified 1907 somatic substitutions, which exhibited dramatic replicative strand bias, predominantly C > T and A > G on the mitochondrial heavy strand. Th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.02935

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Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
3
Issue:
October
Article number:
e02935
Publication date:
2014-01-01
DOI:
EISSN:
2050-084X
ISSN:
2050-084X
Source identifiers:
485988

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