Journal article
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
- Abstract:
-
Steady-state hematopoiesis is altered on infection, but the cellular and molecular mechanisms driving these changes are largely unknown. Modulation of hematopoiesis is essential to increase the output of the appropriate type of effector cell required to combat the invading pathogen. In the present study, we demonstrate that the pro-inflammatory cytokine IFNγ is involved in orchestrating inflammation-induced myelopoiesis. Using both mouse models and in vitro assays, we show that IFNγ induces t...
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- Publisher copy:
- 10.1182/blood-2011-07-367706
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Authors
Bibliographic Details
- Journal:
- Blood
- Volume:
- 119
- Issue:
- 6
- Pages:
- 1543-1554
- Publication date:
- 2012-02-01
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- Source identifiers:
-
480331
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:480331
- UUID:
-
uuid:1b9a8ac7-638d-4329-875e-c97b431a31f6
- Local pid:
- pubs:480331
- Deposit date:
- 2014-08-22
Terms of use
- Copyright date:
- 2012
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