Journal article icon

Journal article

IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.

Abstract:

Steady-state hematopoiesis is altered on infection, but the cellular and molecular mechanisms driving these changes are largely unknown. Modulation of hematopoiesis is essential to increase the output of the appropriate type of effector cell required to combat the invading pathogen. In the present study, we demonstrate that the pro-inflammatory cytokine IFNγ is involved in orchestrating inflammation-induced myelopoiesis. Using both mouse models and in vitro assays, we show that IFNγ induces t...

Expand abstract

Actions


Access Document


Authors


de Bruin, AM More by this author
Libregts, SF More by this author
Valkhof, M More by this author
Expand authors...
Journal:
Blood
Volume:
119
Issue:
6
Pages:
1543-1554
Publication date:
2012-02-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:1b9a8ac7-638d-4329-875e-c97b431a31f6
Source identifiers:
480331
Local pid:
pubs:480331

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP