Self management of oral anticoagulation: randomised trial.

Journal article

OBJECTIVE: To determine the clinical effectiveness of self management compared with routine care in patients on long term oral anticoagulants. DESIGN: Multicentre open randomised controlled trial. SETTING: Midlands region of the UK. PARTICIPANTS: 617 patients aged over 18 and receiving warfarin randomised to intervention (n = 337) and routine care (n = from 2470 invited; 193/337 (57%) completed the 12 month intervention. INTERVENTION: Intervention patients used a point of care device to measure international normalised ratio twice a week and a simple dosing chart to interpret their dose of warfarin. MAIN OUTCOME MEASURE: Percentage of time spent within the therapeutic range of international normalised ratio. RESULTS: No significant differences were found in percentage of time in the therapeutic range between self management and routine care (70% v 68%). Self managed patients with poor control before the study showed an improvement in control that was not seen in the routine care group. Nine patients (2.8/100 patient years) had serious adverse events in the self managed group, compared with seven (2.7/100 patient years) in the routine care arm (chi2(df = 1) = 0.02, P = 0.89). CONCLUSION: With appropriate training, self management is safe and reliable for a sizeable proportion of patients receiving oral anticoagulation treatment. It may improve the time spent the therapeutic range for patients with initially poor control. Trial registration ISRCTN 19313375.

Authors: Fitzmaurice, D; Murray, E; McCahon, D; Holder, R; Raftery, J

• Publication status: Published
• Journal: BMJ (Clinical research ed.)
• Volume: 331
• Issue: 7524
• Pages: 1057
• Publication date: 2005-11-01
• DOI: 10.1136/bmj.38618.580903.AE
• EISSN: 1756-1833
• ISSN: 0959-8138
• Language: English
• Keywords: Treatment Outcome; Male; Female; Administration, Oral; International Normalized Ratio; Point-of-Care Systems; Middle Aged; Humans; Warfarin; Anticoagulants; Self Care; Aged; Adult