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Rapid endothelial cell-selective loading of connexin 40 antibody blocks endothelium-derived hyperpolarizing factor dilation in rat small mesenteric arteries.

Abstract:

In resistance arteries, spread of hyperpolarization from the endothelium to the adjacent smooth muscle is suggested to be a crucial component of dilation resulting from endothelium-derived hyperpolarizing factor (EDHF). To probe the role of endothelial gap junctions in EDHF-mediated dilation, we developed a method, which was originally used to load membrane impermeant molecules into cells in culture, to load connexin (Cx)-specific inhibitory molecules rapidly (approximately 15 minutes) into e...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Sandow, SL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Journal:
Circulation research
Volume:
97
Issue:
4
Pages:
399-407
Publication date:
2005-08-05
DOI:
EISSN:
1524-4571
ISSN:
0009-7330
URN:
uuid:1b94c93a-5543-4c43-b108-acc1a1a0ee6d
Source identifiers:
106389
Local pid:
pubs:106389

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