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Journal article

Genetic determinants of HSP70 gene expression following heat shock.

Abstract:

The regulation of heat shock protein expression is of significant physiological and pathophysiological significance. Here we show that genetic diversity is an important determinant of heat shock protein 70 expression involving local, likely cis-acting, polymorphisms. We define DNA sequence variation for the highly homologous HSPA1A and HSPA1B genes in the major histocompatibility complex on chromosome 6p21 and establish quantitative and specific assays for determining transcript abundance. We...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/hmg/ddq418

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Knight, J
Grant:
074318
075491/Z/04
Publisher:
Oxford University Press
Journal:
Human molecular genetics More from this journal
Volume:
19
Issue:
24
Pages:
4939-4947
Publication date:
2010-12-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Language:
English
Keywords:
UUID:
uuid:1b929f92-081d-4c66-95e0-08c33f2c4c29
Local pid:
pubs:83817
Source identifiers:
83817
Deposit date:
2012-12-19

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