Journal article
Genetic determinants of HSP70 gene expression following heat shock.
- Abstract:
-
The regulation of heat shock protein expression is of significant physiological and pathophysiological significance. Here we show that genetic diversity is an important determinant of heat shock protein 70 expression involving local, likely cis-acting, polymorphisms. We define DNA sequence variation for the highly homologous HSPA1A and HSPA1B genes in the major histocompatibility complex on chromosome 6p21 and establish quantitative and specific assays for determining transcript abundance. We...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Human molecular genetics Journal website
- Volume:
- 19
- Issue:
- 24
- Pages:
- 4939-4947
- Publication date:
- 2010-12-01
- DOI:
- EISSN:
-
1460-2083
- ISSN:
-
0964-6906
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:1b929f92-081d-4c66-95e0-08c33f2c4c29
- Local pid:
- pubs:83817
- Source identifiers:
-
83817
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Narelle Maugeri, Jayachandran Radhakrishnan and Julian C Knight
- Copyright date:
- 2010
- Notes:
- Copyright © 2010 Narelle Maugeri, Jayachandran Radhakrishnan and Julian C. Knight. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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