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Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease.

Abstract:

BACKGROUND: Although dietary folate fortification lowers plasma homocysteine and may reduce cardiovascular risk, high-dose folic acid therapy appears to not alter clinical outcome. Folic acid and its principal circulating metabolite, 5-methyltetrahydrofolate, improve vascular function, but mechanisms relating folate dose to vascular function remain unclear. We compared the effects of folic acid on human vessels using pharmacological high-dose versus low-dose treatment, equivalent to dietary f...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
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Journal:
Circulation
Volume:
115
Issue:
17
Pages:
2262-2270
Publication date:
2007-05-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:1b8fed1b-b154-418c-9009-815ea40b012a
Source identifiers:
104841
Local pid:
pubs:104841

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