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Effect of post-injury NMDA antagonist treatment on long-term Fos expression and hyperalgesia in a model of chronic neuropathic pain.

Abstract:

Chronic constriction injury (CCI) of the sciatic nerve results in persistent mechanical hyperalgesia together with Fos protein expression in the lumbar spinal cord. We have examined the relationship between mechanical hyperalgesia and Fos expression within the lumbar spinal cord on days 14, 35 and 55 after either CCI or sham operation. To determine the role of NMDA receptor mechanisms in the maintenance of hyperalgesia and Fos expression, the NMDA antagonist MK-801 (0.3 mg kg-1 s.c.) was admi...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
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Journal:
Brain research
Volume:
822
Issue:
1-2
Pages:
220-227
Publication date:
1999-03-05
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
URN:
uuid:1b8f98ed-04f1-4c8d-99cd-a6f233172687
Source identifiers:
31452
Local pid:
pubs:31452

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