- Abstract:
-
Chronic constriction injury (CCI) of the sciatic nerve results in persistent mechanical hyperalgesia together with Fos protein expression in the lumbar spinal cord. We have examined the relationship between mechanical hyperalgesia and Fos expression within the lumbar spinal cord on days 14, 35 and 55 after either CCI or sham operation. To determine the role of NMDA receptor mechanisms in the maintenance of hyperalgesia and Fos expression, the NMDA antagonist MK-801 (0.3 mg kg-1 s.c.) was admi...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0006-8993(99)01161-0
-
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- Journal:
- Brain research
- Volume:
- 822
- Issue:
- 1-2
- Pages:
- 220-227
- Publication date:
- 1999-03-05
- DOI:
- EISSN:
-
1872-6240
- ISSN:
-
0006-8993
- URN:
-
uuid:1b8f98ed-04f1-4c8d-99cd-a6f233172687
- Source identifiers:
-
31452
- Local pid:
- pubs:31452
- Language:
- English
- Keywords:
- Copyright date:
- 1999
Journal article
Effect of post-injury NMDA antagonist treatment on long-term Fos expression and hyperalgesia in a model of chronic neuropathic pain.
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