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Thesis

Theory and simulation of twisted DNA duplexes

Alternative title:
The impact of flexible, bent, or damaged DNA sequences in molecular tweezers experiments on DNA duplexes, and nucleotide-level molecular simulations of P-DNA and L-DNA
Abstract:

We use basic statistical mechanics and computer simulations with coarse-grained models to investigate the response of (inhomogeneous) DNA duplexes to linear and torsional mechanical stress. While the response of homogeneous DNA to more modest external stresses has been studied in detail, much less is know about DNA response to very strong over or under twisting, or about the biologically relevant case of inhomogeneous DNA under external torsion. By simulating geometries that resemble singl...

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Division:
MPLS
Department:
Physics
Sub department:
Theoretical Physics
Department:
FabricNano
Role:
Author

Contributors

Department:
University of Oxford
Role:
Supervisor
Department:
University of Oxford
Role:
Supervisor
Department:
University of Oxford
Role:
Examiner
Department:
Katholieke Universiteit Leuven
Role:
Examiner
Engineering & Physical Sciences Research Council More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:1b8cf9be-8034-4aed-b488-35e7a3c7c97f
Deposit date:
2019-06-05

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