Assembling the presynaptic active zone.

Journal article

Rapid neurotransmission depends on the structural and functional integrity of synaptic connections. How synapses assemble is currently being intensely investigated to help our understanding of neuronal development and synaptic plasticity. Here we focus on the assembly of the presynaptic active zone, which regulates the synaptic vesicle exo/endo-cycle and is characterized by ultrastructural specializations and large scaffold proteins. While genetic and biochemical studies from rodents, Caenorh...

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Authors: Owald, D; Sigrist, S

• Publication status: Published
• Journal: Current opinion in neurobiology
• Volume: 19
• Issue: 3
• Pages: 311-318
• Publication date: 2009-06-01
• DOI: 10.1016/j.conb.2009.03.003
• EISSN: 1873-6882
• ISSN: 0959-4388
• Language: English
• Keywords: Models, Neurological; Presynaptic Terminals; Synaptic Transmission; Time Factors; Synapses; Animals