Detection and monitoring of progressive degeneration of osteoarthritic cartilage by MRI.

Journal article

Osteoarthritis (OA) results from a failure of cells within the joint to maintain the balance between synthesis and degradation of the extracellular matrix. OA is a major cause of pain and disability in the elderly yet there is at present no effective treatment to slow down or halt progressive loss of joint function. This is partly because the condition is heterogeneous with obscure pathogenesis but also because there are no specific laboratory tests or screening procedures that provide a specific diagnosis of early OA. There is a clear need to be able to define onset of characteristic pathological changes when intervention would be timely and to monitor the natural history up to the stage of radiologically detected damage. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Authors: Tyler, J; Watson, P; Koh, H; Herrod, N; Robson, M

• Publication status: Published
• Publisher: Informa Healthcare
• Journal: Acta orthopaedica Scandinavica. Supplementum
• Volume: 266
• Issue: S266
• Pages: 130-138
• Publication date: 1995-10-01
• DOI: 10.3109/17453679509157668
• ISSN: 0300-8827
• Language: English
• Keywords: Magnetic Resonance Imaging; Male; Guinea Pigs; Cross-Sectional Studies; Aging; Adult; Reference Values; Longitudinal Studies; Humans; Osteoarthritis; Aged; Knee Joint; Animals; Middle Aged; Cartilage, Articular; Female; Image Processing, Computer-Assisted