Journal article
Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia
- Abstract:
-
Epigenetic therapies demonstrate significant clinical activity in acute myeloid leukemia (AML) and myelodysplasia (MDS) and constitute an important new class of therapeutic agents. However hematological responses are not durable and disease relapse appears inevitable. Experimentally, leukemic stem/progenitor cells (LSC) propagate disease in animal models of AML and it has been postulated that their relative chemo-resistance contributes to disease relapse. We serially measured LSC numbers in p...
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Bibliographic Details
- Journal:
- Leukemia
- Volume:
- 27
- Issue:
- 5
- Pages:
- 1028-1036
- Publication date:
- 2013-05-01
- DOI:
- EISSN:
-
1476-5551
- ISSN:
-
0887-6924
- Source identifiers:
-
403856
Item Description
- Pubs id:
-
pubs:403856
- UUID:
-
uuid:1b8054c2-db43-4653-bae4-1b975ae57de0
- Local pid:
- pubs:403856
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2013
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