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Journal article

Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia

Abstract:

Epigenetic therapies demonstrate significant clinical activity in acute myeloid leukemia (AML) and myelodysplasia (MDS) and constitute an important new class of therapeutic agents. However hematological responses are not durable and disease relapse appears inevitable. Experimentally, leukemic stem/progenitor cells (LSC) propagate disease in animal models of AML and it has been postulated that their relative chemo-resistance contributes to disease relapse. We serially measured LSC numbers in p...

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Publisher copy:
10.1038/leu.2012.312

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Journal:
Leukemia
Volume:
27
Issue:
5
Pages:
1028-1036
Publication date:
2013-05-05
DOI:
EISSN:
1476-5551
ISSN:
0887-6924
URN:
uuid:1b8054c2-db43-4653-bae4-1b975ae57de0
Source identifiers:
403856
Local pid:
pubs:403856

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