- Abstract:
-
Epigenetic therapies demonstrate significant clinical activity in acute myeloid leukemia (AML) and myelodysplasia (MDS) and constitute an important new class of therapeutic agents. However hematological responses are not durable and disease relapse appears inevitable. Experimentally, leukemic stem/progenitor cells (LSC) propagate disease in animal models of AML and it has been postulated that their relative chemo-resistance contributes to disease relapse. We serially measured LSC numbers in p...
Expand abstract - Publisher copy:
- 10.1038/leu.2012.312
-
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- Journal:
- Leukemia
- Volume:
- 27
- Issue:
- 5
- Pages:
- 1028-1036
- Publication date:
- 2013-05-05
- DOI:
- EISSN:
-
1476-5551
- ISSN:
-
0887-6924
- URN:
-
uuid:1b8054c2-db43-4653-bae4-1b975ae57de0
- Source identifiers:
-
403856
- Local pid:
- pubs:403856
- Copyright date:
- 2013
Journal article
Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia
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