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Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy.

Abstract:

The hepatitis B virus (HBV) cytotoxic T lymphocyte (CTL) response in patients with chronic HBV infection is generally weak or totally undetectable. This inability to mount protective CTL responses is believed to be a crucial determinant of viral persistence, and its correction represents an important objective of immune therapies for chronic hepatitis B. However, amplification of CTL responses in vivo may be ineffective if HBV-specific CD8 cells are either absent or nonresponsive to exogenous...

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Publication status:
Published

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Publisher copy:
10.1053/jhep.2001.23045

Authors


Journal:
Hepatology (Baltimore, Md.) More from this journal
Volume:
33
Issue:
4
Pages:
963-971
Publication date:
2001-04-01
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
Language:
English
Keywords:
Pubs id:
pubs:10925
UUID:
uuid:1b72a51f-e236-48e1-a471-05994d06d0b7
Local pid:
pubs:10925
Source identifiers:
10925
Deposit date:
2012-12-19

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