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Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis.

Abstract:

It is hypothesized that the balance of cytokines produced by Th1/Th2 subsets of T helper cells plays an important role in the development of autoimmune diseases. Murine collagen-induced arthritis (CIA) is an example of an autoimmune disease in which immunization with cartilage-derived type II collagen induces, firstly, a T cell response to type II collagen and, secondly, the manifestation of a destructive inflammatory response in affected joints. We have investigated the role of Th1/Th2 respo...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830260716

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
European journal of immunology
Volume:
26
Issue:
7
Pages:
1511-1518
Publication date:
1996-07-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Source identifiers:
481621
Language:
English
Keywords:
Pubs id:
pubs:481621
UUID:
uuid:1b69473a-40d5-4fe3-b227-389339628045
Local pid:
pubs:481621
Deposit date:
2014-08-29

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