Journal article icon

Journal article

Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123).

Abstract:

Previous studies suggest that dephosphorylation of connexin43 (Cx43) is related to uncoupling of gap junction communication, which plays an important role in the genesis of ischemia-induced ventricular tachycardia. We studied changes in Cx43 phosphorylation during global ischemia in the absence and presence of the antiarrhythmic peptide analogue rotigaptide (formerly known as ZP123). Phosphorylation analysis was performed on Cx43 purified from isolated perfused rat hearts using matrix-assiste...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.yjmcc.2006.03.005

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
Expand authors...
Journal:
Journal of molecular and cellular cardiology
Volume:
40
Issue:
6
Pages:
790-798
Publication date:
2006-06-01
DOI:
EISSN:
1095-8584
ISSN:
0022-2828
Source identifiers:
384618
Language:
English
Keywords:
Pubs id:
pubs:384618
UUID:
uuid:1b68b42c-01e5-45a8-a805-3ef1574a1365
Local pid:
pubs:384618
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP