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Genome wide profiling of altered gene expression in the neocortex of Alzheimer's disease.

Abstract:

Alzheimer's disease (AD) is characterized by a complex neurodegenerative process affecting multiple genes and proteins in the neocortex, many of which have not been well-studied. In this study, we investigated genome-wide gene alterations in the temporal cortex of a well-characterized cohort of AD patients using a recently developed microarray platform, and compared some of the transcript changes with immunoblotting. Of the 5485 genes found to be significantly altered in AD, there were consis...

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Publication status:
Published

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Publisher copy:
10.1002/jnr.22290

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Vinters, HV More by this author
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Journal:
Journal of neuroscience research
Volume:
88
Issue:
6
Pages:
1157-1169
Publication date:
2010-05-05
DOI:
EISSN:
1097-4547
ISSN:
0360-4012
URN:
uuid:1b63b6dc-9cfe-4cb3-b5a4-4e6b022f3b84
Source identifiers:
195512
Local pid:
pubs:195512

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