Back to Search

Journal article

Selective loss of PARG restores PARylation and counteracts PARP inhibitor-mediated synthetic lethality

Abstract:: Inhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have recently entered the clinic for the treatment of homologous recombination (HR)-deficient cancers. Despite the success of this approach, drug resistance is a clinical hurdle, and we poorly understand how cancer cells escape the deadly effects of PARPi without restoring the HR pathway. By combining genetic screens with multi-omics analysis of matched PARPi-sensitive and -resistant Brca2-mutated mouse mammary tumors, we identified loss...
Expand abstract
Collapse abstract

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Gogola, E., Duarte, A. A., de Ruiter, J. R., Wiegant, W. W., Schmid, J. A., de Bruijn, R., James, D. I., Llobet, S. G., Vis, D. J., Annunziato, S., van den Broek, B., Barazas, M., Kersbergen, A., van de Ven, M., Tarsounas, M., Ogilvie, D. J., van Vugt, M., Wessels, L. F. A., Bartkova, J., … Rottenberg, S. (2018). Selective loss of PARG restores PARylation and counteracts PARP inhibitor-mediated synthetic lethality. Cancer Cell, 33(6), 1078–1093.e12.

MLA Style

Gogola, E., et al. “Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.” Cancer Cell, vol. 33, no. 6, Cell Press , 2018, pp. 1078–93.e12.

Chicago Style

Gogola, E, AA Duarte, JR de Ruiter, WW Wiegant, JA Schmid, R de Bruijn, DI James, et al. 2018. “Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.” Cancer Cell 33 (6): 1078–93.e12.
Tweet
Print

Access Document

Publisher copy:: 10.1016/j.ccell.2018.05.008

Authors

+ Gogola, E More by this author

Role:

Author

+ Duarte, AA More by this author

Role:

Author

+ de Ruiter, JR More by this author

Role:

Author

+ Wiegant, WW More by this author

Role:

Author

+ Schmid, JA More by this author

Role:

Author

More authors...

Funding

Cancer Research UK More from this funder

Bibliographic Details

Publisher:: Cell Press Publisher's website
Journal:: Cancer Cell Journal website
Volume:: 33
Issue:: 6
Pages:: 1078-1093.e12
Publication date:: 2018-06-11
Acceptance date:: 2018-05-14
DOI:: 10.1016/j.ccell.2018.05.008
EISSN:: 1878-3686
ISSN:: 1535-6108
Pmid:: 29894693

Item Description

Language:: English
Keywords:: replication fork

PARP inhibitor

BRCA1

drug resistance

PARP1

PARylation

PARG

BRCA2

homologous recombination
Pubs id:: 857080
Local pid:: pubs:857080
Deposit date:: 2020-06-04

Terms of use

Copyright holder:: Elsevier Inc.
Copyright date:: 2018
Rights statement:: © 2018 Elsevier Inc.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

Metrics

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP