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Journal article

What makes a good genetic association study?

Abstract:

Genetic association studies are central to efforts to identify and characterise genomic variants underlying susceptibility to multifactorial disease. However, obtaining robust replication of initial association findings has proved difficult. Much of this inconsistency can be attributed to inadequacies in study design, implementation, and interpretation - inadequately powered sample groups are a major concern. Several additional factors affect the quality of any given association study, with a...

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Authors


Hattersley, AT More by this author
McCarthy, MI More by this author
Journal:
Lancet
Volume:
366
Issue:
9493
Pages:
1315-1323
Publication date:
2005-10-08
DOI:
ISSN:
0140-6736
URN:
uuid:1b603f95-8b39-42ac-a948-201eb4526e74
Source identifiers:
93104
Local pid:
pubs:93104
Language:
English

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