- Abstract:
-
OBJECTIVE: To determine whether selective blockade of tumor necrosis factor receptor I (TNFRI) affects spontaneous proinflammatory cytokine and chemokine production in ex vivo-cultured human rheumatoid arthritis synovial membrane mononuclear cells (MNCs) and to compare this response to that of TNF ligand blockade using etanercept. METHODS: A bispecific, single variable-domain antibody (anti-TNFRI moiety plus an albumin binding moiety [TNFRI-AlbudAb]) was used to selectively block TNFRI. Inhib...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/art.38055
-
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- Journal:
- Arthritis and rheumatism
- Volume:
- 65
- Issue:
- 9
- Pages:
- 2262-2273
- Publication date:
- 2013-09-05
- DOI:
- EISSN:
-
1529-0131
- ISSN:
-
0004-3591
- URN:
-
uuid:1b5232b4-f2a6-4351-9cff-60a9980b63b5
- Source identifiers:
-
407691
- Local pid:
- pubs:407691
- Copyright date:
- 2013
Journal article
Selective blockade of tumor necrosis factor receptor I inhibits proinflammatory cytokine and chemokine production in human rheumatoid arthritis synovial membrane cell cultures.
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