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Selective blockade of tumor necrosis factor receptor I inhibits proinflammatory cytokine and chemokine production in human rheumatoid arthritis synovial membrane cell cultures.

Abstract:

OBJECTIVE: To determine whether selective blockade of tumor necrosis factor receptor I (TNFRI) affects spontaneous proinflammatory cytokine and chemokine production in ex vivo-cultured human rheumatoid arthritis synovial membrane mononuclear cells (MNCs) and to compare this response to that of TNF ligand blockade using etanercept. METHODS: A bispecific, single variable-domain antibody (anti-TNFRI moiety plus an albumin binding moiety [TNFRI-AlbudAb]) was used to selectively block TNFRI. Inhib...

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Publication status:
Published

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Publisher copy:
10.1002/art.38055

Authors


Schmidt, EM More by this author
Giddins, G More by this author
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Journal:
Arthritis and rheumatism
Volume:
65
Issue:
9
Pages:
2262-2273
Publication date:
2013-09-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:1b5232b4-f2a6-4351-9cff-60a9980b63b5
Source identifiers:
407691
Local pid:
pubs:407691

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