Journal article
A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells.
- Abstract:
-
Autophagy is a conserved constitutive cellular process, responsible for the degradation of dysfunctional proteins and organelles. Autophagy plays a role in many diseases such as neurodegeneration and cancer; however, to date, conventional autophagy detection techniques are not suitable for clinical samples. We have developed a high throughput, statistically robust technique that quantitates autophagy in primary human leukocytes using the Image stream, an imaging flow cytometer. We validate th...
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- Publication status:
- Published
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- Publisher copy:
- 10.4161/auto.18935
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Authors
Bibliographic Details
- Journal:
- Autophagy
- Volume:
- 8
- Issue:
- 4
- Pages:
- 677-689
- Publication date:
- 2012-04-01
- DOI:
- EISSN:
-
1554-8635
- ISSN:
-
1554-8627
- Source identifiers:
-
254233
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:254233
- UUID:
-
uuid:1b48f687-ece9-4498-93db-210aabe95f95
- Local pid:
- pubs:254233
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
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