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A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells.

Abstract:

Autophagy is a conserved constitutive cellular process, responsible for the degradation of dysfunctional proteins and organelles. Autophagy plays a role in many diseases such as neurodegeneration and cancer; however, to date, conventional autophagy detection techniques are not suitable for clinical samples. We have developed a high throughput, statistically robust technique that quantitates autophagy in primary human leukocytes using the Image stream, an imaging flow cytometer. We validate th...

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Publication status:
Published

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Publisher copy:
10.4161/auto.18935

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Journal:
Autophagy
Volume:
8
Issue:
4
Pages:
677-689
Publication date:
2012-04-05
DOI:
EISSN:
1554-8635
ISSN:
1554-8627
URN:
uuid:1b48f687-ece9-4498-93db-210aabe95f95
Source identifiers:
254233
Local pid:
pubs:254233

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