Journal article
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.
- Abstract:
-
Lymphatic vessels are essential for immune surveillance, tissue fluid homeostasis and fat absorption. Defects in lymphatic vessel formation or function cause lymphedema. Here we show that the vascular endothelial growth factor C (VEGF-C) is required for the initial steps in lymphatic development. In Vegfc-/- mice, endothelial cells commit to the lymphatic lineage but do not sprout to form lymph vessels. Sprouting was rescued by VEGF-C and VEGF-D but not by VEGF, indicating VEGF receptor 3 spe...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/ni1013
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Authors
Bibliographic Details
- Journal:
- Nature immunology
- Volume:
- 5
- Issue:
- 1
- Pages:
- 74-80
- Publication date:
- 2004-01-01
- DOI:
- EISSN:
-
1529-2916
- ISSN:
-
1529-2908
- Source identifiers:
-
102747
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:102747
- UUID:
-
uuid:1b3fc12b-ed6e-4093-b6a4-058c49e0659d
- Local pid:
- pubs:102747
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2004
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