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Journal article

Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.

Abstract:

Lymphatic vessels are essential for immune surveillance, tissue fluid homeostasis and fat absorption. Defects in lymphatic vessel formation or function cause lymphedema. Here we show that the vascular endothelial growth factor C (VEGF-C) is required for the initial steps in lymphatic development. In Vegfc-/- mice, endothelial cells commit to the lymphatic lineage but do not sprout to form lymph vessels. Sprouting was rescued by VEGF-C and VEGF-D but not by VEGF, indicating VEGF receptor 3 spe...

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Publication status:
Published

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Publisher copy:
10.1038/ni1013

Authors


Karkkainen, MJ More by this author
Partanen, J More by this author
Taipale, J More by this author
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Journal:
Nature immunology
Volume:
5
Issue:
1
Pages:
74-80
Publication date:
2004-01-05
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
URN:
uuid:1b3fc12b-ed6e-4093-b6a4-058c49e0659d
Source identifiers:
102747
Local pid:
pubs:102747

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