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Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis.

Abstract:

Dissecting the molecular mechanisms used by developmental regulators is essential to understand tissue specification/differentiation. SCL/TAL-1 is a basic helix-loop-helix transcription factor absolutely critical for hematopoietic stem/progenitor cell specification and lineage maturation. Using in vitro and forced expression experimental systems, we previously suggested that SCL might have DNA-binding-independent functions. Here, to assess the requirements for SCL DNA-binding activity in vivo...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research
Role:
Author
Journal:
Blood
Volume:
112
Issue:
4
Pages:
1056-1067
Publication date:
2008-08-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:1b3e5652-1418-4435-971e-14c3723d183d
Source identifiers:
34273
Local pid:
pubs:34273

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