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Enhanced mutagenic potential of 8-oxo-7,8-dihydroguanine when present within a clustered DNA damage site.

Abstract:

The formation of clustered DNA damage sites is a unique feature of ionizing radiation. Recent studies have shown that the repair of lesions within clusters may be compromised, but little is understood about the mutagenic consequences of such damage sites. Using a plasmid-based method, damaged DNA containing uracil positioned at 1-5 bp separations from 8-oxo-7,8-dihydroguanine on the complementary strand was transfected into wild-type Escherichia coli or into strains lacking the DNA glycosylas...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gkh150

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
Journal:
Nucleic acids research
Volume:
32
Issue:
1
Pages:
263-270
Publication date:
2004-01-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:1b3c1d82-b41f-4d5c-a85a-4af3416046ff
Source identifiers:
131198
Local pid:
pubs:131198

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