Reduced anxiety-related behaviour in transgenic mice overexpressing serotonin 1A receptors.

Kusserow, H; Davies, B; Hörtnagl, H; Voigt, I; Stroh, T; Bert, B; Deng, DR; Fink, H; Veh, R; Theuring, F

Women's Health Collection

Journal article

Reduced anxiety-related behaviour in transgenic mice overexpressing serotonin 1A receptors.

Abstract:: Serotonergic neurons play a major role in the modulation of emotion and behaviour. Especially knockout studies have revealed a role for the serotonin(1A) (5-HT(1A)) receptor in anxiety related behaviour. Mutant animals exhibit enhanced anxiety-like responses, possibly resulting from impaired autoinhibitory control of midbrain serotonergic neurons. To further elucidate the role of the 5-HT(1A) receptors in affective behaviour, a complementary approach has been used and transgenic mice overexpressing this receptor subtype have been generated. The expression of the active 5-HT(1A) receptor protein as indicated by autoradiography was transiently increased during early postnatal development (P1.5) as compared to wild-type mice. Within the next 2 weeks, the increase in receptor binding vanished and was also not apparent in adult animals indicating adaptive changes in the regulation of 5-HT(1A) receptor expression. Although no evidence for increased receptor binding in the brains of adult homozygous mice was found by autoradiography, typical phenotypic changes indicative of 5-HT(1A) receptor overactivity were apparent. Transgenic mice revealed a reduced molar ratio of 5-hydroxyindoleacetic acid to serotonin in several brain areas and elevated serotonin values in the hippocampus and striatum. Moreover, anxiety-like behaviour was decreased in male and female transgenic mice and body temperature was lowered in male transgenic mice in comparison with heterozygous and wild-type mice. These findings further underline the pivotal role of 5-HT(1A) receptors in the homeostasis of anxiety-like behaviour and the crucial importance of stimulation of the 5-HT(1A) receptor during the early postnatal development for normal anxiety-like behaviour throughout life.

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APA Style

Kusserow, H., Davies, B., Hörtnagl, H., Voigt, I., Stroh, T., Bert, B., Deng, D. R., Fink, H., Veh, R., & Theuring, F. (2004). Reduced anxiety-related behaviour in transgenic mice overexpressing serotonin 1A receptors. Brain Research. Molecular Brain Research, 129(1-2), 104–116.

MLA Style

Kusserow, H, et al. “Reduced Anxiety-Related Behaviour in Transgenic Mice Overexpressing Serotonin 1A Receptors.” Brain Research. Molecular Brain Research, vol. 129, nos. 1-2, 2004, pp. 104–16.

Chicago Style

Kusserow, H, B Davies, H Hörtnagl, et al. 2004. “Reduced Anxiety-Related Behaviour in Transgenic Mice Overexpressing Serotonin 1A Receptors.” Brain Research. Molecular Brain Research 129 (1-2): 104–16.
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