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Reduced anxiety-related behaviour in transgenic mice overexpressing serotonin 1A receptors.

Abstract:

Serotonergic neurons play a major role in the modulation of emotion and behaviour. Especially knockout studies have revealed a role for the serotonin(1A) (5-HT(1A)) receptor in anxiety related behaviour. Mutant animals exhibit enhanced anxiety-like responses, possibly resulting from impaired autoinhibitory control of midbrain serotonergic neurons. To further elucidate the role of the 5-HT(1A) receptors in affective behaviour, a complementary approach has been used and transgenic mice overexpr...

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Journal:
Brain research. Molecular brain research More from this journal
Volume:
129
Issue:
1-2
Pages:
104-116
Publication date:
2004-10-01
DOI:
ISSN:
0169-328X
Language:
English
Keywords:
Pubs id:
pubs:95875
UUID:
uuid:1b3c1495-0073-4e61-831d-f1f39798ec7b
Local pid:
pubs:95875
Source identifiers:
95875
Deposit date:
2012-12-19

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