Effects of a cardioselective beta-blocker on postprandial triglyceride-rich lipoproteins, low density lipoprotein particle size and glucose-insulin homeostasis in middle-aged men with modestly increased cardiovascular risk.

Journal article

Beta-adrenergic receptor-blocking agents are commonly used for treatment of hypertension, angina pectoris and arrhythmias and as secondary prevention after myocardial infarction. The modest protection against myocardial infarction conferred by these compounds in primary-preventive studies has suggested that beneficial effects of beta-blockade are counteracted by known adverse influences on lipid and glucose metabolism. As most beta-blockers increase plasma triglycerides and decrease the high ...

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Authors: Boquist, S; Ruotolo, G; Hellénius, M; Danell-Toverud, K; Karpe, F

• Publication status: Published
• Journal: Atherosclerosis
• Volume: 137
• Issue: 2
• Pages: 391-400
• Publication date: 1998-04-01
• DOI: 10.1016/s0021-9150(97)00278-5
• EISSN: 1879-1484
• ISSN: 0021-9150
• Language: English
• Keywords: Chylomicrons; Adult; Cross-Over Studies; Risk Factors; Blood Glucose; Male; Apolipoproteins B; Metoprolol; Cardiovascular Diseases; Follow-Up Studies; Double-Blind Method; Apolipoprotein B-100; Triglycerides; Apolipoprotein B-48; Fatty Acids, Nonesterified; Lipoproteins, VLDL; Adrenergic beta-Antagonists; Postprandial Period; Insulin; Humans; Homeostasis; Middle Aged; Lipoproteins, LDL