Fluid resuscitation of adults with severe falciparum malaria: effects on Acid-base status, renal function, and extravascular lung water.

Journal article

OBJECTIVE: To evaluate the efficacy and safety of liberal fluid resuscitation of adults with severe malaria. DESIGN, SETTING, PATIENTS, AND METHODS: Twenty-eight Bangladeshi and Indian adults with severe falciparum malaria received crystalloid resuscitation guided by transpulmonary thermodilution (PiCCO) in an intensive care setting. Systemic hemodynamics, microvascular indices and measures of acidosis, renal function, and pulmonary edema were followed prospectively. RESULTS: All patients wer...

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Authors: Hanson, J; Lam, S; Mohanty, S; Alam, S; Pattnaik, R

• Publication status: Published
• Journal: Critical care medicine
• Volume: 41
• Issue: 4
• Pages: 972-981
• Publication date: 2013-04-01
• DOI: 10.1097/ccm.0b013e31827466d2
• EISSN: 1530-0293
• ISSN: 0090-3493
• Language: English
• Keywords: Female; Humans; Bangladesh; Young Adult; Isotonic Solutions; Blood Pressure; Rehydration Solutions; Malaria, Falciparum; Extravascular Lung Water; Acid-Base Equilibrium; Fluid Therapy; Pulmonary Edema; Adult; Male; Severity of Illness Index; Hemodynamics