Journal article icon

Journal article

Astroglial overproduction of TGF-beta 1 enhances inflammatory central nervous system disease in transgenic mice .

Abstract:

Cerebral expression of the injury response cytokine transforming growth factor-beta 1 (TGF-beta 1) has been found to be increased in several neurological diseases but it remains unclear whether its function is primarily beneficial or detrimental. Here we show that transgenic (tg) mice that overexpress bioactive (TGF-beta 1 in the central nervous system (CNS) and show no overt phenotype in the unmanipulated state, are more susceptible to the immune-mediated CNS disease experimental autoimmune ...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Wyss-Coray, T More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Brooker, MJ More by this author
Journal:
Journal of neuroimmunology
Volume:
77
Issue:
1
Pages:
45-50
Publication date:
1997-07-05
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
URN:
uuid:1b34d997-1f5d-4e79-b174-4f0fc71d0cb2
Source identifiers:
36061
Local pid:
pubs:36061

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP