Journal article
Neutrophils promote hepatic metastasis growth through fibroblast growth factor 2–dependent angiogenesis in mice
- Abstract:
-
Hepatic metastases are amenable to ablation; however, many patients are not suitable candidates for such therapy and recurrence is common. The tumor microenvironment is known to be essential for metastatic growth, yet identification of plausible targets for cancer therapy in the microenvironment has proven elusive. We found that human colorectal cancer liver metastases and murine gastrointestinal experimental liver metastases are infiltrated by neutrophils. Plasticity in neutrophils has recen...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Hepatology Journal website
- Volume:
- 65
- Issue:
- 6
- Pages:
- 1920–1935
- Publication date:
- 2017-05-02
- Acceptance date:
- 2017-01-24
- DOI:
- EISSN:
-
1527-3350
- ISSN:
-
0270-9139
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:675879
- UUID:
-
uuid:1b30acf5-3382-4ed2-a353-f1da86a1b4a3
- Local pid:
- pubs:675879
- Source identifiers:
-
675879
- Deposit date:
- 2017-04-24
Terms of use
- Copyright holder:
- American Association for the Study of Liver Diseases
- Copyright date:
- 2017
- Rights statement:
- © 2017 by the American Association for the Study of Liver Diseases.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Wiley at https://doi.org/10.1002/hep.29088
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