Rolling and stationary cytoadhesion of red blood cells parasitized by Plasmodium falciparum: separate roles for ICAM-1, CD36 and thrombospondin.

Journal article

Adhesion of parasitized erythrocytes to microvascular endothelium is a central event in the pathogenesis of severe falciparum malaria. We have characterized the adhesion of flowing parasitized red blood cells to three of the known endothelial receptors coated on plastic surfaces (CD36, intercellular adhesion molecule-1 (ICAM-1) and thrombospondin (TSP)), and also to cells bearing these receptors (human umbilical vein endothelial cells (HUVEC) and platelets). All of the surfaces could mediate ...

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Authors: Cooke, B; Berendt, A; Craig, A; MacGregor, J; Newbold, C

• Publication status: Published
• Journal: British journal of haematology
• Volume: 87
• Issue: 1
• Pages: 162-170
• Publication date: 1994-05-01
• DOI: 10.1111/j.1365-2141.1994.tb04887.x
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Erythrocytes; Cell Adhesion; Cell Adhesion Molecules; Blood Platelets; Humans; Stress, Mechanical; Intercellular Adhesion Molecule-1; Animals; Endothelium, Vascular; Cells, Cultured; Malaria, Falciparum; Plasmodium falciparum; Thrombospondins; Antigens, CD; Antigens, CD36; Membrane Glycoproteins