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Rolling and stationary cytoadhesion of red blood cells parasitized by Plasmodium falciparum: separate roles for ICAM-1, CD36 and thrombospondin.

Abstract:

Adhesion of parasitized erythrocytes to microvascular endothelium is a central event in the pathogenesis of severe falciparum malaria. We have characterized the adhesion of flowing parasitized red blood cells to three of the known endothelial receptors coated on plastic surfaces (CD36, intercellular adhesion molecule-1 (ICAM-1) and thrombospondin (TSP)), and also to cells bearing these receptors (human umbilical vein endothelial cells (HUVEC) and platelets). All of the surfaces could mediate ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Journal:
British journal of haematology More from this journal
Volume:
87
Issue:
1
Pages:
162-170
Publication date:
1994-05-01
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
Language:
English
Keywords:
Pubs id:
pubs:102
UUID:
uuid:1b2bfcde-15fa-437f-adc7-de4501df4def
Local pid:
pubs:102
Source identifiers:
102
Deposit date:
2012-12-19

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