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Substance P (NK1) receptors in the cingulate cortex in unipolar and bipolar mood disorder and schizophrenia.

Abstract:

BACKGROUND: The substance P receptor (neurokinin-1 receptor) has been implicated in stress responses and anxiety traits in the rodent, and neurokinin-1 receptor antagonism may have antidepressant and anxiolytic effects. This suggests that the function and/or expression of neurokinin-1 receptor might be affected in subjects with mood disorders. METHODS: We measured neurokinin-1 receptor densities in the anterior cingulate cortex in subjects with unipolar (major) depression (n = 13), bipolar di...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Journal:
Biological psychiatry
Volume:
47
Issue:
1
Pages:
80-83
Publication date:
2000-01-05
DOI:
EISSN:
1873-2402
ISSN:
0006-3223
URN:
uuid:1b247f67-93f0-4720-9f11-783324ce9317
Source identifiers:
97999
Local pid:
pubs:97999

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