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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.

Abstract:

The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 population controls generated by the Wellcome Trust Case Control Consortium, we set out to detect replicated diabetes association signals through analysis of 3757 additional cases and 5346 controls and by integration of our findings with equivalent data from other international consortia. We detected diabetes susceptibility loc...

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Publication status:
Published

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Publisher copy:
10.1126/science.1142364

Authors


Zeggini, E More by this author
Weedon, MN More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Frayling, TM More by this author
Elliott, KS More by this author
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Journal:
Science (New York, N.Y.)
Volume:
316
Issue:
5829
Pages:
1336-1341
Publication date:
2007-06-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:1b244ae6-9e81-4278-8fcf-d9f60c4f2963
Source identifiers:
28989
Local pid:
pubs:28989

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