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Pharmacokinetics of primaquine in man. II. Comparison of acute vs chronic dosage in Thai subjects.

Abstract:

We have investigated the pharmacokinetics of primaquine after acute and chronic administration of the drug to five healthy Thai volunteers. After acute dosage (15 mg p.o.) mean (+/- s.d.) peak plasma concentrations of 65.0 +/- 34.7 ng ml-1 were achieved within 2 +/- 1h. Thereafter plasma drug concentrations declined monoexponentially with a mean elimination half life of 4.4 +/- 1.4 h. The mean (+/- s.d.) oral clearance was 37.6 +/- 15.5 1 h-1. These values are in broad agreement with values o...

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Publication status:
Published

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Journal:
British journal of clinical pharmacology More from this journal
Volume:
19
Issue:
6
Pages:
751-755
Publication date:
1985-06-01
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
Language:
English
Keywords:
Pubs id:
pubs:61105
UUID:
uuid:1b22cd3d-a72e-406e-99bf-4287dda4cf72
Local pid:
pubs:61105
Source identifiers:
61105
Deposit date:
2012-12-19

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