Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease.

Journal article

We present here a genome-wide map of abnormalities found in diagnostic samples from 45 adults and adolescents with acute lymphoblastic leukemia (ALL). A 500K SNP array analysis uncovered frequent genetic abnormalities, with cryptic deletions constituting half of the detected changes, implying that microdeletions are a characteristic feature of this malignancy. Importantly, the pattern of deletions resembled that recently reported in pediatric ALL, suggesting that adult, adolescent, and childh...

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Authors: Paulsson, K; Cazier, J; Macdougall, F; Stevens, J; Stasevich, I

• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 105
• Issue: 18
• Pages: 6708-6713
• Publication date: 2008-05-01
• DOI: 10.1073/pnas.0800408105
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Gene Deletion; Cell Cycle; Middle Aged; Lymphopoiesis; Adolescent; Aged; Humans; Adult; Genome, Human; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Polymorphism, Single Nucleotide; Chromosome Aberrations; Genes, Neoplasm; Child; B-Lymphocytes