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Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease.

Abstract:

We present here a genome-wide map of abnormalities found in diagnostic samples from 45 adults and adolescents with acute lymphoblastic leukemia (ALL). A 500K SNP array analysis uncovered frequent genetic abnormalities, with cryptic deletions constituting half of the detected changes, implying that microdeletions are a characteristic feature of this malignancy. Importantly, the pattern of deletions resembled that recently reported in pediatric ALL, suggesting that adult, adolescent, and childh...

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Publisher copy:
10.1073/pnas.0800408105

Authors


Paulsson, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Macdougall, F More by this author
Stevens, J More by this author
Stasevich, I More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
105
Issue:
18
Pages:
6708-6713
Publication date:
2008-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:1b1fab4f-cc5f-4a27-b0d5-c6b4e42672e9
Source identifiers:
290928
Local pid:
pubs:290928

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