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Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo.

Abstract:

Osteoblasts play a crucial role in the hematopoietic stem cell (HSC) niche; however, an overall increase in their number does not necessarily promote hematopoiesis. Because the activity of osteoblasts and osteoclasts is coordinately regulated, we hypothesized that active bone-resorbing osteoclasts would participate in HSC niche maintenance. Mice treated with bisphosphonates exhibited a decrease in proportion and absolute number of Lin(-)cKit(+)Sca1(+) Flk2(-) (LKS Flk2(-)) and long-term cultu...

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Publication status:
Published

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Journal:
Blood More from this journal
Volume:
117
Issue:
5
Pages:
1540-1549
Publication date:
2011-02-01
DOI:
EISSN:
1528-0020
ISSN:
0006-4971

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