Efficient base catalyzed alkylation reactions with aziridine electrophiles.

Journal article

N-Mesitylene sulfonyl and N-tosyl aziridines have been identified as effective electrophiles in alkylation reactions of carbon acids catalyzed by the organic phosphorine base BEMP; yields of up to 99% for a range of pro-nucleophiles under mild reaction conditions are reported.

Authors: Moss, T; Alba, A; Hepworth, D; Dixon, D

• Publication status: Published
• Journal: Chemical Communications
• Issue: 21
• Pages: 2474-2476
• Publication date: 2008-06-01
• DOI: 10.1039/b802447b
• EISSN: 1364-548X
• ISSN: 1359-7345
• Language: English
• Keywords: Catalysis; Esters; Stereoisomerism; Organophosphorus Compounds; Molecular Structure; Alkylation; Aziridines; Heterocyclic Compounds, 1-Ring