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Journal article

Haplotype-specific linkage disequilibrium patterns define the genetic topography of the human MHC.

Abstract:

Detailed knowledge of linkage disequilibrium (LD) is regarded as a prerequisite for population-based disease gene mapping. Variable patterns across the human genome are now recognized, both between regions and populations. Here, we demonstrate that LD may also vary within a genomic region in a haplotype-specific manner. In 864 Caucasian unrelated individuals, we describe haplotype-specific LD patterns across the human MHC by the construction of gene-specific allelic haplotypes at 25 loci betw...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/12.6.647

Authors


Journal:
Human molecular genetics More from this journal
Volume:
12
Issue:
6
Pages:
647-656
Publication date:
2003-03-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Language:
English
Keywords:
Pubs id:
pubs:135340
UUID:
uuid:1b0d4596-3fdd-4abf-9323-c32ca80364b7
Local pid:
pubs:135340
Source identifiers:
135340
Deposit date:
2012-12-19

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