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Journal article

DNA scaffolds support stable and uniform peptide nanopores

Abstract:

The assembly of peptides into membrane-spanning nanopores might be promoted by scaffolds to pre-organize the structures. Such scaffolds could enable the construction of uniform pores of various sizes and pores with controlled permutations around a central axis. Here, we show that DNA nanostructures can serve as scaffolds to arrange peptides derived from the octameric polysaccharide transporter Wza to form uniform nanopores in planar lipid bilayers. Our ring-shaped DNA scaffold is assembled fr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41565-018-0139-6

Authors


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Role:
Author
ORCID:
0000-0003-4793-9923
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Institution:
University of Oxford
Division:
MPLS Division
Department:
Physics; Condensed Matter Physics
Role:
Author
ORCID:
0000-0003-0359-8928
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Role:
Author
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Name:
Horizon 2020
Grant:
655660
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Name:
Biotechnology and Biological Sciences Research Council
Publisher:
Nature Publishing Group
Journal:
Nature Nanotechnology More from this journal
Volume:
13
Issue:
5
Pages:
739–745
Publication date:
2018-05-28
Acceptance date:
2018-04-04
DOI:
EISSN:
1748-3395
ISSN:
1748-3387
Pmid:
29808001
Language:
English
Keywords:
Pubs id:
pubs:854494
UUID:
uuid:1afec893-3f0f-462c-b883-b661e4a0f77b
Local pid:
pubs:854494
Source identifiers:
854494
Deposit date:
2018-06-27

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