Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases.

Journal article

Some immune system disorders, such as type 1 diabetes, multiple sclerosis (MS), and rheumatoid arthritis (RA), share common features: the presence of autoantibodies and self-reactive T-cells, and a genetic association with the major histocompatibility complex. We have previously published evidence, from 1,708 families, for linkage and association of a haplotype of three markers in the D18S487 region of chromosome 18q21 with type 1 diabetes. Here, the three markers were typed in an independent...

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Authors: Merriman, T; Cordell, H; Eaves, I; Danoy, P; Coraddu, F

• Publication status: Published
• Journal: Diabetes
• Volume: 50
• Issue: 1
• Pages: 184-194
• Publication date: 2001-01-01
• DOI: 10.2337/diabetes.50.1.184
• EISSN: 1939-327X
• ISSN: 0012-1797
• Language: English
• Keywords: Chromosomes, Human, Pair 18; Sequence Homology; Haplotypes; Multiple Sclerosis; Rats; Animals; Microsatellite Repeats; Diabetes Mellitus, Type 1; Arthritis, Rheumatoid; Autoimmune Diseases; Phenotype; Chromosome Mapping; Mice; Genes, DCC; Genetic Linkage; Humans