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Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix

Abstract:

Citrullination of proteins, a post-translational conversion of arginine residues to citrulline, is recognized in rheumatoid arthritis, but largely undocumented in cancer. Here we show that citrullination of the extracellular matrix by cancer cell derived peptidylarginine deiminase 4 (PAD4) is essential for the growth of liver metastases from colorectal cancer (CRC). Using proteomics, we demonstrate that liver metastases exhibit higher levels of citrullination and PAD4 than unaffected liver, p...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-07306-7

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Oxford college:
University College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
Role:
Author
ORCID:
0000-0003-2997-4194
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Oxford college:
Pembroke College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Oxford college:
Jesus College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
ORCID:
0000-0002-8674-702X
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Publisher:
Springer Nature Publisher's website
Journal:
Nature communications Journal website
Volume:
9
Pages:
Article: 4783
Publication date:
2018-11-14
Acceptance date:
2018-10-22
DOI:
EISSN:
2041-1723
Pubs id:
pubs:942832
URN:
uri:1aea7343-3f0f-4038-9025-647275230067
UUID:
uuid:1aea7343-3f0f-4038-9025-647275230067
Local pid:
pubs:942832
Language:
English

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